Farid Abedin-Dorkoosh, Ph.D.

E-mail: fdorkoosh@gmail.com

dorkoosh@tums.ac.ir

Mobile/Viber: +98-912-5467448

EDUCATION:

Ph.D., 2002, Leiden University,

The Netherlands

Thesis: Peptide drug delivery

Major: Pharmaceutical Technology

Minor: Biopharmaceutics

Pharm. D., l993, Tehran Azad University,

Tehran, Iran

Thesis: Development of parenteral formulations

Major: Pharmacy

Minor: Pharmaceutics

Diploma in

Management, 2010, Management Chartered institute, London, UK

WORK EXPERIENCES:

Dates Employed: 02/2008-Present

Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IRAN

Responsibilities are teaching courses to undergraduates and postgraduates in the fields of pharmaceutics, pharmacoeconomy and pharmaceutical management. Moreover, is doing research in various fields of novel drug delivery systems and nanotechnology both in PharmD and PhD level.

Accomplishments:

Establishing a patent office in Tehran University of Medical Sciences
Managing more than 30 PharmD thesis in the field of pharmaceutics
Managing 2 PharmD thesis in the field of pharmacoeconomy and pharmaceutical managemet
Managing 10 PhD students in various fields of novel drug delivery systems, nanotechnology, and gene delivery
Teaching the following courses in PharmD: Physical Pharmacy (Thermodynamics), Pharmaceutics (general pharmaceutical dosage forms, Injectable dosage forms, cosmetic formulations, solid dosage forms), Management (Marketing, Management of Innovation, Patenting)
Teaching the following courses in PhD: Physical Pharmacy (Modern Thermodynamics), Pharmaceutics (Peroral drug delivery, Injectable dosage forms), Pharmacoeconomy (General Management, IP rights, International Marketing, Project Management, Control Management, R&D Management)
Teaching to MPH, Master of Nanotechnology, Master of Pharmaceutical Engineering and PhD of Nanobiotechnology students

Dates Employed: 03/2004-11/2007

Head Pharmaceutical R&D Department, Synthon BV,

P.O.Box 7071, 6503 GN Nijmegen, The Netherlands

Responsibilities include managing the pharmaceutical R&D department, technical support for development of various drug deliveries and pharmaceutical formulations, leading the research group both in research and development phases of pharmaceutical formulation.

Scientific and technical support to researchers and project leaders for developing new formulations and initiating new projects with respect to novel drug delivery systems.

Accomplishments:

Establishing effective R&D processes for the whole drug development traject.
Managing drug development traject by considering product life cycle management.
Management of people with Pharmaceutical R&D and enhance the performance of drug development.
Establish strategic plans for development of a drug product.
Directing development of finished products and supporting the team scientifically.
Directing all project team meetings, generated action items, and timelines; reviewed all necessary technical and scientific reports on the status of the projects, and provided updates to management.

Investigating the possible new formulations for existing chemical entities.
Developing oral disintegrating tablets.
Developing oral solutions.
Developing modified release formulations using polymeric matrix systems or various extended release coating polymers.
Developing pellets using high shear technique or extrusion-spheronization technique.

Dates Employed: 05/2002-02/2004

Senior development scientist, Department of pharmaceutics, Organon International,

P.O.Box 20, 5340 BH Oss, The Netherlands

Responsibilities are to develop novel drug delivery systems and to co-ordinate the project related statement of work, locate and negotiate the possible mutual scientific collaboration with the other research groups and centers.

Scientific leading and guiding the research group for developing novel formulations.

Scientific support to innovation group.

Accomplishments:

Effectively coordinating all activities related to drug development,
Facilitating, and monitoring product formulation from pre-clinical stages through clinical batches.

Investigated the absorption pathways of drugs which are metabolized in the intestine and to investigate on the active transport of drugs in the intestine and role of P-gp and MRP transporters in the absorption of active compounds.
Developing preliminary formulations for an anti-schizophrenia compound and to investigate the best routes of administration for such a compounds.
Developing a novel transmucosal buccal patch for delivery of hydrophilic macromolecular drugs.

Dates Employed: 08/1997-04/1998

Head of cosmetic production unit, Laleh Ekbatan Company

Hafez St. Corner of Taleghani St. Fith floor, Tehran-Iran

Responsibilities included managing the production unit and directing the cosmetic department. Controlling the performance of department under GMP conditions and guiding the personal to achieve the high performance of the unit.

Accomplishments:

Have developed a cream formulation for softening of the skin.
Have developed a wax for depletion of the hair on the skin.
Compiled a high GMP and GLP conditions in the production and laboratory units.
Scientific support to managing directors for high performance of cosmetic department.

Dates Employed: 08/1995-07/1997

Clinical pharmacist, 501 Hospital pharmacy

Kargar St. Shiraz Gharbi St., Tehran-Iran

Responsibilities were organizing drug therapy for patients in the hospital and collaborating with physicians for performing clinical trials in well-defined process.

Accomplishments:

Managing the hospital pharmacy for efficient work performance.
Computerize the drug delivery in the pharmacy.
Coordinating the clinical trials in the hospital.

Dates Employed: 02/1994-07/1995

Head of research department in IPDIC company

Fatemi Sq. Beginning of Biston St. Tehran-Iran

Responsibilities were developing new formulations for parenteral administrations of various active compounds and also managing the research group for their both scientific activities and technical performance in the formulation department.

Accomplishments:

For more than 30 active compounds, new parenteral formulations were developed.
The GMP scaling up has been performed for the developed delivery systems.
A well-organized information center was initiated within the company for scientific support of all scientists within the company.
Special support was given to quality control department for enhancing their performance capacity.
All documentations for getting the Drug Master File for each formulation were prepared and submitted to ministry of health for getting the approval for production of the new formulations.

JOB-RELATED TRAINING COURSES:

Scientific

Application of Twin Screw Extruder in Drug Delivery 2006
Experimental Design (STAVEX) in Basel, Switzerland 2005
Pharmacokinetics and Pharmacodynamic at Organon 2003
Gene therapy and gene delivery at the Medical Faculty of Leiden University 2001
ULLA summer school in Denmark 1999
Introductory course on drug research at Leiden uinversity 1999
International course on laboratory animal science at Utrecht University 1999
GMP and GLP regulatory course 1995
Solid Dosage Form Development 1994

b. Managerial

Industrial and Organizational Documentation Systems (Qumas), The Netherlands 2007
International training on intellectual property and management of innovation (At World Intellectual Property Organization in Geneva, Switzerland) 2005
Team leadership 1994

JOB-RELATED SKILLS:

Formulation and preformulation investigation on different pharmaceutical dosage forms such as solid dosage forms, parenteral and non-parenteral delivery systems.
Awareness of GMP and GLP regulations and application of these regulations in scale up process.
Haveing both theoretical and working knowledge of the cGMP and performance of all the activities according to cGMP.
Drug development in phase I, II and III of clinical trials.
Organizing of projects in a serial development processes from early clinical and toxicological studies till phase IV of clinical studies.

Formulation of peptides and bioanalysis of proteins.
Working with different cell cultures such as Caco-2 or Calu-3 cell cultures, etc.

Different analytical analysis methods such as HPLC, UV, RIA, ELISA, FTIR, CLSM.
Microcomputer applications (spreadsheet, graphics, presentation, and word processing) in both stand-alone and local areas network environments.
Skilled in the use of most of the pharmaceutical processing technologies and analytical instrumentations both at laboratory and at industrial scales.

HONORS, AWARDS

AAPS graduate award (2002)

Pharmaceutical Technology and Drug Delivery (PT/DD) graduate award dedicated by American Association of Pharmaceutical scientists for outstanding PhD research in peroral peptide drug delivery (AAPS; Toronto, Canada 2002).

CRS-Capsugel Graduate/Postdoc Award (2001)

for outstanding graduate research dedicated by the Young Investigator Awards Committee of the Controlled Release Society (The 28^th international symposium on Controlled Release of Bioactive Materials; San Diego, USA 2001).

GENERAL MEMBERSHIPS

2011-present Board Member of Nanomedicine Society of Iran

2011-present Research Board Member of virtual institute of medical biotechnology

2010-present Board Member of Controlled Release Society of Iran

2009-2010 Webcast committee member at CRS, USA

2007-2009 Head of education committee at CRS, USA

2003-2009 Member of educational committee at CRS, USA

2003-2007 Member of award committee for 3M-garduate award

2001-2004 Member, American Association of Pharmaceutical Scientists (AAPS)

1998-present Member, Controlled Release Society (CRS)

1995-present Member of Iranian Ministry of health organization

1993-present Member of Iranian Pharmaceutical Association

SCIENTIFIC MEMBERSHIPS

2012-present Editor in Chief of Journal of Pharmacoeconomics and Pharmaceutical Management, Iran

2012-present Editorial Board Member of Journal of Research in Pharmacy Practice, Iran

2011-present PhD Board Member of Pharmacoeconomics and Pharmaceutical Management, Iran

2011-present Editorial Board Member of Controlled Release Journal, Iran

2010- present Editorial Board Member of Drug Delivery Letters, Germany

2010-2015 Editorial Board Member of Drug Delivery and Translational Research, USA

2007-present Editorial Board Member of Research in Pharmaceutical Sciences, Iran

2016-present Associate Regional Editor of Pharmaceutical Nanotechnology, UK

AREA OF RESEARCH INTEREST

Development, formulation and designing novel drug delivery systems
Nanotechnology
Peptide & Gene delivery
Biotechnology of peptides and natural products
Formulation of pharmaceutical dosage forms

ACADEMIC AND TEACHING ACTIVITIES:

2008- Present PharmD = “Physical Pharmacy 1, Pharmaceutics 3, Management”

PhD = “Physical Pharmacy, Pharmaceutical Technology, Novel Drug Delivery Systems, Intellectual Property Rights, General Management, International Marketing, R&D management, Control Management”

2005- 2008 “Novel Drug Delivery Systems, Peptide and Gene Delivery”

Biopharmaceutical Technology courses for pharmacy PhD student, Isfahan faculty of pharmacy, Isfahan Medical University, Isfahan, Iran

1998-2002 "Solid dosage forms and formulations,”

Pharmaceutics course for biopharmaceutical undergraduate students, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands

EXECUTIVE ACTIVITIES:

2010 Scientific committee member of 3^rd International Congress on Nanoscience and nanotechnology, 9-11 of November 2010, Shiraz, IRAN

2008-present Head of Patent Office of Tehran University of Medical Sciences, IRAN

PhD thesis defended
No	Title	Student Name
1	Preparation and evaluation of injectable Chitosan-based implant for intratumoral gene delivery	Sepideh Safari
2	Design and development of intraocular polymeric implant systems for long-term controlled-release of clindamycin phosphate for toxoplasmic retinochoroiditis	Lena Tamadon
3	Design of Nanoparticles loaded Acyclovir for Controlled Delivery System	Shadab Shahsavari
4	Experimental studies and modeling process for preparation of nanoparticles using supercritical CO₂	Javad Karimi Sabet
5	Preparation and Characterization on Nanoparticles Composed of Quaternized Aromatic Derivatives of Chitosan for Oral Insulin Delivery	Reza Mahjub
6	Preparation and Characterization of a Novel Polymeric Micelle Based on Hyaluronic Acid and Phospholipids for Targeted Delivery of Paclitaxel	Ebrahim Saadat
7	Preparation of Insulin Nano-particles using dipeptides and vitamin B12 derivatives of chitosan and TMC for oral delivery	Nersi Jafari-Omid
8	Preparation of Teriparatide nanocomposite formulation using nanoparticles loaded hydrogel	Nika Bahari-Javan
9	Preparation and formulation of Fingolimod controlled release by means of PHBV Nanospheres loaded in grafted Alginate hybrid system	Leila Rezaeei Shirmard

PharmD thesis defended
Student Name	Title	No
Ali Keshavarz	Preparation of raloxifene nanoparticles using supercritical CO₂	1
Elnaz-sadat Shamsa	Preparation and characterization of long chin alkylated chitosan for use in insulin oral drug delivery	2
Maryam Mansorpour	Preparation and characterization of alginate/ trimethyl chitosan nanoparticles containing cationic β-cyclodextrin polymers for insulin oral delivery	3
Marzieh Zargaran	Preparation and evaluation of tyrosine and alanine chelate with iron for treatment of iron deficiency anemia	4
Pouya Dehghan Klilshadi	Formulation and physic-chemical evaluation of pluronic micelles containing paclitaxel and lapatinib	5
Naimeh Shakour	Formulation & evaluation of novel polymeric micelle for articular delivery of triamcinolone	6
Zeynab Ehsanfar	Development and characterization of Parenteral Implant Containing Methotrexate-Magnetic Nanoparticles	7
Betolhoda Morovati Mahini	Design and formulation of olanzapine nanosystems using MIP	8
Mujan Radmehr	Preparation and evaluation of nanoparticles composed of N-Trimethyl-O-Carboxymethyl chitosan for oral delivery of Heparin	9
Hooman Sadeghi	Privatization of pharmaceutical industry in developing countries : A qualitative study on the experience of Iran	10
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